Experimental methods for the purification, analysis and characterization of proteins and nucleic acids. Work on small research projects.

The lecture teaches central reactions and metabolic pathways of biochemistry as well as molecular biology with emphasis on chemical and partly biophysical aspects.

The course covers biophysical methods for characterising conformational transitions and reaction mechanisms of proteins and other biological macromolecules. It is especially suited for students in the Biology MSc Majors “Structural Biology & Biophysics”, “Biochemistry”and “Chemical Biology”, as well as for MSc students of “Chemistry and Interdisciplinary Natural Sciences”.

Laboratory course with advanced experiments in the plant sciences, biochemistry, and structural biology.

This 1st year Laboratory course introduces the student to the entire range of classical and modern molecular biosciences. During this course (Praktikum GL BioI) the students will do three praktikum days in:- Biochemistry- Cell Biology I- Microbiology- Plant Anantomy & Ecology(total of 12 experiments)Each experiment takes one full day.

The course provides an introduction to Biochemistry / Molecular Biology with some emphasis on chemical and biophysical aspects.

The course provides an introduction to Biochemistry / Molecular Biology with some emphasis on chemical and biophysical aspects.

This Concept Course explores the molecular and structural mechanisms underlying key processes in gene expression and protein biogenesis. The course will present advanced mechanistic aspects of the organization and regulation of chromatin, transcription, RNA maturation, translation, and the pathways of protein folding, modification, trageting to membranes, and quality control.

Microanalytics of proteins and proteomes. Edman sequencing and chemical modification of proteins, modern proteome analytics, including MALDI-TOF and electrospray mass spectrometry, HPLC separation of peptides after proteolytic proteome digestion. Actual lieterature in protein chemistry.

Molekular biology and Biophysics III: Biophysics of protein folding, membrane proteins and biophysics of membranes, enzymatic catalysis, katalytic RNA and RNAi, proteome analytics, actual literature in protein biophysics and structural biology

The course consists of a series of research seminars on Structural Biology and Biophysics, given by both scientists of the National Center of Competence in Research (NCCR) in Structural Biology and external speakers.

The course provides an overview of several interdisciplinary and quantitative approaches to the study of biological problems, including transient spectroscopic techniques, biosensors and advanced light microscopy techniques. A brief tutorial on MatLab is followed by numerical analyses and modelling examples of biological problems.

This course on advanced topics in molecular biology and biochemistry covers the structure and function of large cellular protein assemblies. The lecturers will cover topics including membrane proteins, protein glycosylation, horizonal gene transfer, microbial cytomotive filaments, and microbial contractile injection systems.

Students will carry out defined research projects related to the current research topics of the groups of Prof. Glockshuber and Prof. Weber-Ban. The topics include mechanistic studies on the assembly of adhesive pili from pathogenic bacteria, disulfide bond formation in the bacterial periplasm, ATP-dependent chaperone-protease complexes and formation of amyloid deposits in Alzheimer's disese.