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551-0307-00L 6 Credits BSC , MSC , NDS D-BSSE , D-PHYS , D-INFK , D-BIOL

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Macromolecular Structure and Biophysics

Lecturers & Examiners: Prof. em. Dr. Timothy J. Richmond, Prof. em. Dr. Rudolf Glockshuber, Prof. em. Dr. Fritz K. Winkler, Prof. Dr. Nenad Ban, Prof. Dr. Eilika Weber-Ban, Prof. Dr. Frédéric Allain, Prof. Dr. Kaspar Locher

VVZ CR n/a

Last Updated: 2026-02-05 15:14:52

Abstract

Part 1: Biophysics of protein folding, mmbrane proteins and biophysics of membranes, enzymatic catalysis, catalytic RNA and RNAi, current topics in protein biophysics and structural biologyPart 2: The lecture covers: DNA and RNA structures; Protein/DNA and protein/RNA complexes and thermodynamic and kinetic aspects of their interactions.

Objective

Part 1: Understanding of structure-function relationships in proteins and in protein folding, detailed understanding of biophysics and physical methods as well as modern methods for protein purification and microanalytics. Part 2: The basics of protein, DNA and RNA structures and their complexes are described, with special emphasis on functionality and energetic aspects. Fundamental mechanisms of biomacromolecular recognition are examined

Resources

Lecture Notes

Part 1: Scripts on the individual topics can be found underhttp://www.mol.biol.ethz.ch/teaching.Part 2: A script with diagrams and literature list is distributed at the beginning of each lecture.

Literature

Part 1: Basics: - Creighton, T.E., Proteins, Freeman, (1993) - Fersht, A., Enzyme, Structure and Mechanism in Protein Science (1999), Freeman - Berg, Tymoczko, Stryer: Biochemistry (5th edition), Freeman (2001) Current topics: References will be given during the lectures. Part 2: The lectures are based on current publications. Recommended reading: Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed. (1995). Garland, New York.

General Information

Language: English
Levels: BSC , MSC , NDS
Frequency: Yearly recurring

Examination

Type: session examination
Mode: written 150 minutes
Aids: None

Course Components

Type	Title	Time & Place	Hours
lecture	Macromolecular Structure and Biophysics 1	Mon 09:45-11:30 (HCI J 6)	2 h weekly
lecture	Macromolecular Structure and Biophysics 2	Tue 09:45-11:30 (HCI J 7)	2 h weekly