Mechanisms of biomacromolecular recognition. The basics of protein, DNA and RNA structures and their complexes are described, with special emphasis on functionality and energetic aspects.

The course gives insight into the methodology, areas of application and limitations of the two principal methods for the structure determination of biological macromolecules.

Insight into the methodology, areas of application and limitations of the two principal methods for the structure determination of biological macromolecules.

The course provides an overview of experimental methods for studying function and structure of macromolecules at atomic resolution in solution. The two main methods used are Nuclear Magnetic Resonance (NMR) spectroscopy and Electron Paramagnetic Resonance (EPR) spectroscopy.

The course consists of a series of research seminars on Structural Biology, Biochemistry and Biophysics, given by both scientists of the National Center of Competence in Research (NCCR) in Structural Biology and external speakers. Information on the individual seminars is provided on the following websites:http://www.structuralbiology.uzh.ch/educ002.asphttp://www.biol.ethz.ch/dbiol-cal/index

In this block course, students actively participate in ongoing research projects in the research groups of Profs. Allain, Wüthrich and Dr. Gossert. The students will be tutored in their experimental work by experienced postdoc students. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as exercises and literature work.

This course covers aspects of RNA biology related to gene expression at the posttranscriptional level. These include RNA transcription, processing, alternative splicing, editing, export and translation.

Introduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells.

Introduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells.

The course provides an overview of experimental methods for the determination of high-resolution structures of macromolecules.