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551-0434-00L 6 Credits BSC D-BIOL
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NMR Spectroscopy in Biology

Lecturers: Prof. Dr. Kurt Wüthrich, Prof. em. Dr. Gerhard Wider, Prof. Dr. Frédéric Allain
Examiners: Prof. Dr. Frédéric Allain
VVZ CR n/a

Last Updated: 2026-02-05 15:28:57

Abstract

In this block course, students actively participate in ongoing research projects in the research groups of Profs. Allain, Wider and Wüthrich. The students will be tutored in their experimental work by doctoral or postdoctoral students. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as excercises and literature work.

Objective

The course provides first "hands on" insight into applications of NMR spectroscopy in biological sciences. The course should enable the students to understand the potential and limitations of NMR applied to biological problems.

Content

The topics include studies of protein-RNA interactions, Participation in one of the following projects will be possible: - NMR of RNA - NMR of several protein-RNA complexes (hnRNPF, nPTB, SR proteins) - NMR studies of glycoproteins - dynamics of protein-RNA complexes - Segmental isotopic labeling to study multidomain proteins -Structural and dynamic properties of FtsZ, the bacterial homolog of tubulin - investigations of the ubiquitinom - NMR Methods Development - MR Studies of Membrane Proteins - Structural Biology of Mammalian and Non-mammalian Prion Proteins - NMR Studies of Insect Pheromone-binding Proteins - In vitro Protein Expression for Structure Determination

Resources

Lecture Notes

No script

Literature

Lists of individual reading assignments will be handed out.

General Information

Language
English
Levels
BSC
Frequency
Yearly recurring

Examination

Type
graded semester performance
Es wird nur der hauptverantwortliche Examinator aufgeführt. Weitere Examinatoren: Die oben aufgeführten Dozierenden.

Course Components

Type Title Time & Place Hours
lecture with exercise NMR Spectroscopy in Biology
Permission from lecturers required for all students. Blockkurs im 2. Semesterviertel (beschränkt auf max. 9 Teilnehmende)
  • 13.03 Date 07:45-16:30 (HPK E 33)
  • 14.03 Date 07:45-16:30 (HPK E 33)
  • 18.03 Date 12:45-17:30 (HPK E 33)
  • 19.03 Date 07:45-16:30 (HPK E 33)
  • 20.03 Date 07:45-16:30 (HPK E 33)
  • 09.04 Date 07:45-16:30 (HPK E 33)
  • 11.04 Date 13:45-17:30 (HPK D 24.2)
100 h semesterly

Offered In