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551-0142-00L 6 Credits DS , MSC D-CHAB , D-PHYS , D-BIOL

Structure Determination of Biological Macromolecules by X-ray Crystallography and NMR

Lecturers: Prof. em. Dr. Timothy J. Richmond, Prof. Dr. Kurt Wüthrich, Prof. em. Dr. Gerhard Wider, Prof. Dr. Frédéric Allain
Examiners: Prof. em. Dr. Timothy J. Richmond, Prof. em. Dr. Gerhard Wider, Prof. Dr. Frédéric Allain
VVZ CR n/a

Last Updated: 2026-02-05 15:29:36

Abstract

The course provides an overview of experimental methods for the determination of high-resolution structures of macromolecules.

Objective

Insight into the methodology, areas of application and limitations of the two principal methods for the structure determination of biological macromolecules.

Content

Part I (Deutsch): Methods for the determination of protein structures in solution using nuclear magnetic resonance (NMR). Experimental approaches to the characterization of intramolecular dynamics of proteins. Part II (English): Methods for the determination of the structure of proteins and macromolecular complexes using X-ray diffraction in single crystals.

Resources

Lecture Notes

Part I: Yes.Part II: Full script of each lecture in English.

Literature

1) Wüthrich, K. NMR of Proteins and Nucleic Acids, Wiley-Interscience. 2) Blow, D. Outline of Crystallography for Biologists. Oxford University Press.

General Information

Language
English
Levels
DS , MSC
Frequency
Yearly recurring

Examination

Type
session examination
Mode
written 90 minutes
Aids
None
Language of examination: English or GermanExamination in 2 parts. Duration of X-ray part 45 Min. Duration of NMR part 45 Min.Sprache der Leistungskontrolle Englisch oder Deutsch.Die Prüfung besteht aus zwei Teilen: 45 Min. für X-ray und 45 Min. für NMR

Course Components

Type Title Time & Place Hours
lecture with exercise Structure Determination of Biological Macromolecules by X-ray Crystallography and NMR
Lehrsprache: Part I: Deutsch, Part II: English
  • Thu 14:45-17:30 (HPK D 24.2)
3 h weekly

Offered In