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551-0434-00L 6 Credits BSC D-BIOL
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NMR Spectroscopy in Biology

Lecturers: Prof. Dr. Kurt Wüthrich, Prof. Dr. Frédéric Allain, Dr. Alvar Diego Gossert
Examiners: Prof. Dr. Frédéric Allain
Number of participants limited to 6. The enrolment is done by the D-BIOL study administration. General safety regulations for all block courses: -Whenever possible the distance rules have to be respected -All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed. -The installation and activation of the Swiss Covid-App is highly encouraged -Any additional rules for individual courses have to be respected -Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
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Last Updated: 2026-02-05 15:53:53

Abstract

In this block course, students actively participate in ongoing research projects in the research groups of Profs. Allain, Wüthrich and Dr. Gossert. The students will be tutored in their experimental work by experienced postdoc students. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as exercises and literature work.

Objective

The course provides first "hands on" insight into applications of NMR spectroscopy in biological sciences. The course should enable the students to understand the potential and limitations of NMR applied to biological problems.

Content

The topics include studies of proteins, RNA and protein-RNA interactions, Participation in one of the following projects will be possible: - NMR of RNA - NMR of several protein-RNA complexes (hnRNPF, nPTB, SR proteins) - NMR studies of protein-ligand interactions - dynamics of protein-RNA complexes - Segmental isotopic labeling to study multidomain proteins - NMR Methods Development

Resources

Lecture Notes

No script

Literature

Lists of individual reading assignments will be handed out.

General Information

Language
English
Levels
BSC
Frequency
Yearly recurring

Examination

Type
graded semester performance
Es wird nur der hauptverantwortliche Examinator aufgeführt. Weitere Examinatoren: Die oben aufgeführten Dozierenden.

Course Components

Type Title Time & Place Hours
practical/laboratory course NMR Spectroscopy in Biology
Permission from lecturers required for all students. Block course in the 2nd quarter of the spring semester
  • Tue 12:45-16:30 (HPP L 21)
  • Wed 07:45-16:30 (HPP L 21)
  • Thu 07:45-16:30 (HPP L 21)
  • Fri 07:45-16:30 (HPP L 21)
100 h semesterly

Offered In