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551-1606-01L 1 Credits

Molecular Biology and Biophysics II:Structure Determination of Biological Macromolecules (exercises)

Molekularbio. u. Biophysik II: Ergänzung für Richtung Biologie + Studierende D-PHYS

Lecturers & Examiners: Prof. em. Dr. Timothy J. Richmond, Dr. David Fisher Sargent, Prof. Dr. Kurt Wüthrich, Prof. em. Dr. Gerhard Wider, Prof. Dr. Frédéric Allain
VVZ CR n/a

Last Updated: 2026-02-05 15:09:52

Abstract

Insight into the methodology, areas of application and limitations of the two principal methods for the structure determination of biological macromolecules.

Objective

Insight into the methodology, areas of application and limitations of the two principal methods for the structure determination of biological macromolecules.

Content

The course provides an overview of experimental methods for the determination of high-resolution structures of macromolecules. Part I: Methods for the determination of protein structures in solution using nuclear magnetic resonance (NMR). Experimental approaches to the characterization of intramolecular dynamics of proteins. Part II: Methods for the determination of the structure of proteins and macromolecular complexes using X-ray diffraction in single crystals.

Resources

Lecture Notes

Yes

Literature

1) Wüthrich, K. NMR of Proteins and Nucleic Acids, Wiley-Interscience. 1986. 2) Blow, D. Outline of Crystallography for Biologists. Oxford University Press. 2002.

General Information

Language
English
Frequency
Yearly recurring

Examination

Type
ungraded semester performance

Course Components

Type Title Time & Place Hours
lecture with exercise Molekularbio. u. Biophysik II: Ergänzung für Richtung Biologie + Studierende D-PHYS
  • Thu 14:45-15:30 (HPK D 24.2)
1 h weekly

Offered In