Introduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential.

This course provides the basic concepts of biopharmacy (ADMET, absorption, distribution, metabolism, excretion, toxicity of drugs) and pharmacokinetics. After an introduction to the fundamental parameters and concepts, the participants will study independently and apply and consolidate their knowledge in tutorials.

Introduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential.

Introduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential.

Application of pharmacokinetics, case studies; critical reading of original literature

Knowledge of the major reactions of biotransformation in drug therapy, prediction of possible metabolites of drugs and xenobiotics, recognition of structure elements and reactions which can lead to toxic metabolites. Knowledge of inter- and intraindividual factors influencing metabolism.

The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic and present their work on a one day symposium.

First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.

First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.

Experimental determination of pharmacokinetic parameters in vitro: biotransformation experiments (phase I and II) with rat liver microsomes; determination of partition coefficients in the octanol/buffer system including stability testing; protein binding and displacement studies with bovine serum albumin as binding partner.

State-of-the-art information on drug discovery and development by experts from academia and industry.