Fundamentals about biological networks and practical applications

Epigenetics studies the inheritance of traits that cannot be attributed to changes in the DNA sequence. The lecture will present an overview of different epigenetic phenomena and provide detailed insight into the underlying molecular mechanisms. The role of epigenetic processes in the development of cancer and other disorders will be discussed.

Functional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data.

Storage, handling and analysis of large datasets have become essential in biological research. The course will introduce students to a number of applications of bioinformatics in biology. Freely accessible software tools and databases will be explained and explored in theory and praxis.

Topics include:(i) Processes responsible for stability and variability of genomes and for the control of gene activities, particularly in eukaryotes. (ii) Modern techniques for the analysis of such processes. (iii) Practical applications in basic science, breeding, gene technology, and diagnostics.

Epigenetics studies mitotic and/or meiotic heritable traits that cannot be attributed to changes of the DNA sequence. During the course epigenetic changes of plant development will be analyzed using molecular-genetic techniques.