The goal is to deepen the knowledge gained in the lecture "Krebs: Grundlagen, Ursachen, Therapie". Students get insights in the methods of translational cancer research, with the focus on applications in cancer therapy. Selected topics will be monoclonal antibodies, kinase inhibitors, epigenetic regulators and genetically modified immune cells.

General aspects and etiology of cancer diseases. Molecular events occurring during the development of a cancer cell. Concept of proto-oncogenes and tumor suppressor genes and their function within the cell. Interactions between chemicals and DNA. Test systems to recognize mutagenic chemicals. Basics of epidemiology relevant to cancer. Old and new therapeutic strategies.

Etiology of cancer. Epidemiology. Impact of food, physical activity and infections. Genetic predispositions. Molecular basis of cancer. Oncogenes and tumor suppressor genes. Cancer stem cells and tumor micro-environment. Interactions between chemicals and DNA. Test systems to recognize mutagens. Conventional and new therapeutic strategies. immunotherapy. Therapy with genetically modified cells.

Toxicokinetic and toxicodynamic aspects of xenobiotic interactions with cellular structures and mechanisms. Toxic responses at the level of organs (immune-, neuro-, reproductive and genotoxicity) and organisms. Introduction into developmental toxicology and ecotoxicology.

Toxicokinetic and toxicodynamic aspects of xenobiotic interactions with cellular structures and mechanisms. Toxic responses at the level of organs (immune-, neuro-, reproductive and genotoxicity) and organisms. Introduction into developmental toxicology and ecotoxicology.