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Glycobiology in Drug Development
Last Updated: 2026-02-05 15:23:33
Abstract
For multicellular organisms glycosylation of proteins is vital as glycoproteins play crucial roles in cell-cell communication. Protein-based drugs constitute 25% of new approvals with a majority being glycoproteins. Using selected examples, the course aims at providing insight into our present knowledge on glycosylation-activity relationships, production and analysis of glycoprotein-based drugs.
Objective
A sound insight into the glycobiology of therapeutically used glycoproteins: Knowing - The most important pathways for biosynthesis of glycoproteins - The most important expression systems for production of recombinant glycoproteins - The clinically used glycoproteins - The strengths and limitations of the different methods for the qualitative and quantitative characterization of glycoproteins.
Resources
Lecture Notes
The slides used for the lectures will be provided either as print-outs or by e-mail.
Literature
- Essentials of Glycobiology 1st. edition (2nd edition due in Sept. 2008), Cold Spring Harbor Laboratory Press. - PubMed
General Information
- Language
- English
- Levels
- MSC
- Frequency
- Yearly recurring
Examination
- Type
- graded semester performance
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture | Glycobiology in Drug Development |
|
1 h weekly |