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Reactive Intermediates
Last Updated: 2026-02-05 15:23:42
Abstract
Advanced physical organic chemistry. Methods for the elucidation of reaction mechanisms. Reactive intermediates. Thermochemistry; isotope labeling; cross-over experiments; kinetic isotope effects; thermodynamics-kinetics correlations; solvation and ion pairs; radical reactions; electron transfer; investigation of fast dynamic equilibrium processes by NMR.
Objective
Methods for the elucidation of organic reaction mechanisms.
Content
Thermochemistry: homodesmic reactions, estimation with group increments. Non-kinetic methods: product analysis, labeling with stable isotopes, cross-over experiments. Kinetic methods: establishing intermediates, isotope effects. Thermodynamic-kinetic correlations: LFER, Marcus relation. Solvation and ion pairs. Methods for the investigation of radical reactions: radical clocks, spin trapping, ESR, CIDNP. Redox reactions: cyclic voltammetry, homogeneous electron transfer. Investigation of fast equilibrium processes by NMR.
Resources
Lecture Notes
A printed script, as well as the problems and proposed solution are handed out in the course. This material is also available for download from the web page of the course (as pdf files).
Literature
Additional reading and original publications are cited in the lectures.
General Information
- Language
- English
- Levels
- DS , MSC
- Frequency
- Yearly recurring
Examination
- Type
- session examination
- Mode
- written 60 minutes, oral 30 minutes
- Aids
- keine
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture with exercise | Reactive Intermediates |
|
3 h weekly |