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551-0440-00L 6 Credits BSC D-BIOL

Protein Structure Determination by X-ray Crystallography

Lecturers & Examiners: Prof. Dr. Kaspar Locher
VVZ CR n/a

Last Updated: 2026-02-05 15:28:57

Abstract

This course will guide the student through the main steps of the crystal structure determination of a protein. Students will crystallize a previously purified protein, collect X-ray diffraction data, and solve the structure using computational techniques. Approximately one third of the course will be spent at the lab bench or at the X-ray diffractometer, the rest at the computer.

Objective

The course aims at introducing the principles of protein X-ray crystallography to the students. The major steps include protein crystallization, crystal handling, X-ray data collection and processing, and structure determination as well as interpretation. After completing the course, students should have a general understanding of the process.

General Information

Language
English
Levels
BSC
Frequency
Yearly recurring

Examination

Type
graded semester performance

Course Components

Type Title Time & Place Hours
lecture with exercise Protein Structure Determination by X-ray Crystallography
Permission from lecturers required for all students. Blockkurs im 3. Semesterviertel (beschränkt auf max. 2 Teilnehmende)
  • Tue 12:45-16:30 (HPK D 14.3)
  • Wed 07:45-16:30 (HPK D 14.3)
  • Thu 07:45-16:30 (HPK D 14.3)
  • Fri 07:45-16:30 (HPK D 14.3)
100 h semesterly

Offered In