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Metal-Based Drugs and Drug Development
Last Updated: 2026-02-05 15:13:06
Abstract
Transition metals and their corresponding complexes are often ignored in the classical drug development process. This is in sharp contrast to the fact, that among the 100 stable elements, 2/3 are metals or possess inherent metallic character. Their rich and diverse chemistry potentially provide access to novel compounds with different chemical and structural features useful in medicine.
Objective
The students will learn the different concepts of metal based drug design according to selected examples: - Application of transition metal complexes for diagnosis and therapy - Substitution of classical drugs by metal-based analogues - New concepts for the improvement of drug efficacy through inclusion of a metal center - Use of metal in order to modulate drug metabolism and pharmacokinetics - Metal as structural scaffolds for drugs - Drugs for the therapy of metal detoxification
Resources
Lecture Notes
A script of the lecture covering the different topics will be provided in English.A script is distributed in the course
Literature
The following book can be recommended for this course (but is not mandatory): Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine; Marcel Gielen (Editor), Edward R.T. Tiekink (Editor); ISBN: 978-0-470-86403-6
General Information
- Language
- German
- Levels
- MSC
- Frequency
- Yearly recurring
Examination
- Type
- graded semester performance
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture | Metal-Based Drugs and Drug Development |
|
1 h weekly |