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Natural Product Synthesis
Naturstoffsynthese
Last Updated: 2026-02-05 15:13:16
Abstract
After an introductory overview on secondary metabolites and their biosynthesis, the terms "synthetic strategy and tactics" will be illustrated. In addition, synthetic mehodology, reaction mechanisms and aspects of dynamic stereochemistry will be discussed.
Objective
To get to know some important retrosynthetic concepts. Increase and improve the knowledge concerning synthetically important reactions, their mechanisms and stereochemical implications.
Content
1.1. General aspects of natural products and secondary metabolites 1.2. Biogenetic pathways towards secondary metabolites 2. Mannich-reaction as key step 3. Cyclisations of iminium ions to piperidines 4. Electrocyclic reactions as key steps 5. Radical-induced cyclisation of olefins 6. Cation-induced cyclisation of olefins 7. Cycloaddition reactions as key steps 8. The Hexacyclinol story
Resources
Lecture Notes
A 100-page script in German and solutions for the exercises will be handed out free of charge. All employed overheads will be accessible via EVA-ELBA (URL and password will be disclosed during the first lecture).
Literature
No specific book is required. A standard textbook on Organic Chemistry, like Streitwieser, Vollhard, Morrison-Boyd and so on might be helpful. For students with an above-average interest in the subject, the books cited above in the German version offer additional intellectual stimulus.
General Information
- Language
- German
- Levels
- BSC , MSC
- Frequency
- Yearly recurring
Examination
- Type
- session examination
- Mode
- written 60 minutes
- Aids
- Keine.
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture with exercise | Naturstoffsynthese |
|
3 h weekly |