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Biocompatible Materials I: Molecular Aspects and Fundamentals
Last Updated: 2026-02-05 15:15:02
Abstract
This class is dedicated to Masters- and PhD students and covers: intorduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is dicussed and imprtant techniques from Biomaterials research and development are introduced.
Objective
The class consists of three parts: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application.
Content
Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers. Requirements for credit points: 2 written tests à 45 min each, oral presentation at the end of the term.
Resources
Lecture Notes
Handouts are provided electronically.
Literature
The molecular Biology of the Cell, Alberts et al., 4th Edition, 2002. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002 Handouts provided during the classes and references therin.
General Information
- Language
- English
- Levels
- MSC , NDS
- Frequency
- Yearly recurring
Examination
- Type
- end-of-semester examination
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture | Biocompatible Materials I: Molecular Aspects and Fundamentals |
|
3 h weekly |
Offered In
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Molecular Bioengineering and Biomaterials (Common Major of ETH Zurich and ETH Lausanne. A minimum of 32 credits are necessary for this major.)
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