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Abstract
Der Bereich Praktika, Projekte, Seminare umfasst Lehrveranstaltungen in unterschiedlichen Formaten zum Erwerb von praktischen Kenntnissen und Fertigkeiten. Ausserdem soll selbstständiges Experimentieren und Gestalten gefördert, exploratives Lernen ermöglicht und die Methodik von Projektarbeiten vermittelt werden.
Objective
Bioinformatics and the computational analysis of next-generation sequencing data are the foundation of many medical discoveries, personalized medicine, high throughput diagnostic techniques, and the early detection of cancer and autoimmune diseases. A dedicated machine (called a sequencer) extracts lots of random fragments of a DNA sequence, known as reads. Small, handheld sequencers such as ONT MinION and Flongle make it possible to sequence bacterial and viral genomes on-site. This enables disease outbreak analyses (i.e., for COVID-19 or Ebola) and the on-site analysis of patient samples. A prominent example is the study of the human microbiome in liquid biopsy samples (i.e., blood samples). The microbiome is strongly related to human health and allows for the early diagnosis of diseases like Parkinson's, Alzheimer's, and cancer. In this course, we will cover the basics of genome analysis for medical applications, high-throughput diagnostics, and the early detection and prevention of diseases. Students will experimentally evaluate different algorithms and machine-learning techniques to uncover somatic mutations in cancer and develop tools dedicated to microbiome discovery and high-throughput disease diagnostics. The course is conducted in English. Arvid Gollwitzer is the main supervisor for this course. Please contact him if you are interested in taking this course: [email protected]
Content
Course website: Link