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Abstract
Structure Elucidation of Complex Organic Molecules by NMR
Objective
Structure elucidation of complex organic molecules (including peptides, oligosaccharides and oligonucleotides) by advanced 1D and 2D NMR spectroscopy: Finding the constitution, rel. configuration and the conformation of an unkown molecule. The emphasis of the course is on the selection of optimal strategies for the solution of a given problem. Discussing and solving these problems by the combined application of various 2D methods form an important part of the course. This also includes the use of state-of-the-art methods for computer assisted structure elucdation (CASE) and chemical shift prediction.
Content
Important experiments for structure elucidation. Finding the optimal strategy for a given problem. Spectral processing for optimal results. Spectral interpretation. Assignment strategies for complex molecules. Common Artefacts. Computer assisted structure elucidation incl. introduction to relevant software and hands-on application. Chemical shift prediction. Discussion of challenging problem sets during class.
Resources
Lecture Notes
Handouts (in English) are distributed in the course
Literature
Claridge, T. D. W. High-Resolution NMR Techniques in Organic Chemistry; Elsevier, 2016. Further reading and references in the handouts.