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Abstract
The course includes a general introduction into protein structure and biophysics as well as into the usage of molecular dynamics simulations and other computational methods, protein structure and X-ray techniques, protein NMR for determining protein structure and dynamics as well as for folding studies and protein thermodynamics.
Objective
A 4 hour/week course on all aspects of protein biophysics. The course includes a general introduction into protein structure and biophysics as well as into the usage of molecular dynamics simulations and other computational methods, protein structure and X-ray techniques, protein NMR for determining protein structure and dynamics as well as for folding studies and protein thermodynamics.
Content
The lecture course consists of four parts: 1) non-covalent interactions, properties of water and hydrophobic effect, protein folding and misfolding, molecular dynamics simulations; 2) atomistic simulations of proteins 3) thermodynamics and kinetics of protein folding; 4) single molecule biophysics: single molecule fluorescence spectroscopy, fluorescence correlation spectroscopy, and applications to stochastic processes in biology.