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Advanced Magnetic Resonance - Biological Magnetic Resonance
Last Updated: 2026-06-03 00:07:30
Abstract
The course is for advanced students and covers selected topics from magnetic resonance spectroscopy. It is concerned with inference of structure and dynamics of proteins and their complexes from data obtained by EPR and liquid-state NMR experiments. The special focus is on multi-state and ensemble modelling.
Objective
This course enables students to design experimental strategies for characterization of structure and dynamics of proteins whose flexibility is relevant for their function. Students understand the spin dynamics that encodes sidechain and backbone motion as well as distance information into signals measured by magnetic resonance experiments. They learn to solve the inverse problem of inferring dynamics parameters and distances from the experimental results. They acquire skills in modelling protein ensemble structure from constraints derived by analyzing magnetic resonance data. Students are aware of the complications introduced by the use of spin labels in such experiments and learn how to include such labels in modelling.
Content
• Nitroxide spin labels, their interaction with the environment, and influence of their dynamics on EPR line shapes • Contributions to electron spin decoherence and ways to improve resolution in pulsed EPR • Measurement of electron-electron dipole-dipole interaction and conversion of the primary data to distance distributions • Modelling of spin labels by rotamer libraries • Ensemble modelling with distance distributions • Liquid-state NMR experiments for assessing protein structure and dynamics • Assignment of NMR signals for proteins • Theory of the nuclear Overhauser effect (NOE) • Ensemble modelling with exact NOE constraints • Multistate structure calculation and analysis • Further constraints on protein structure and dynamics from NMR experiments
Resources
Lecture Notes
A script, which covers the topics, will be accessible through the course Moodle
General Information
- Language
- English
- Levels
- MSC
- Frequency
- Yearly recurring
Examination
- Type
- session examination
- Mode
- oral 30 minutes
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture with exercise |
Advanced Magnetic Resonance - Biological Magnetic Resonance
Does not take place this semester.
Previous attendance of 529-0432-00 G Physikalische Chemie IV: Magnetische Resonanz is recommended, but not strictly required
|
No time listed | 3 h weekly |
Offered In
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Electives (Students are free to choose from a range of D-CHAB chemistry courses appropriate to their level of study (please note admission requirements). In case of doubt, contact the student administration.)
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General Electives (Students may choose General Electives from the entire course programme of ETH Zurich - with the following restrictions: courses that belong to the first or second year of a Bachelor curriculum at ETH Zurich as well as courses from GESS "Science in Perspective" are not eligible here. The following courses are explicitly recommended to physics students by their lecturers. (Courses in this list may be assigned to the category "General Electives" directly in myStudies. For the category assignment of other eligible courses keep the choice "no category" and take contact with the Study Administration ( ) after having received the credits.))
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