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Chemical Biology and Synthetic Biochemistry
Last Updated: 2026-06-03 00:07:29
Abstract
Overview of modern chemical biology and synthetic biochemistry techniques, focussed on protein modification and labeling and on methods to endow proteins with novel functionalities.
Objective
After taking this course, students should be capable of the following: A) Recall different possibilities for modifying proteins in vitro and in vivo and their applications in a biological context, B) Understand the chemical and biochemical consequences of modifications and assess the different reaction possibilities in the context of in vivo - in vitro, C) Critically analyze and assess current chemical biology articles D) Question the approaches learned and apply them to new biological problems.
Content
principles of protein labeling and protein modification (fluorescent proteins, enzyme-mediated labeling, bioorthogonal chemistries) advanced genetic code expansion methods (amber suppression, orthogonal ribosomes, unnatural base pairs, genome engineering and genome editing) directed evolution and protein engineering chemical biology of ubiquitin and targeted protein degradation
Resources
Lecture Notes
A script will not be handed out. Handouts to the lecture will be provided through moodle.
Literature
Citations from the original literature relevant to the individual lectures will be assigned during the lectures.
General Information
- Language
- English
- Levels
- MSC
- Frequency
- Yearly recurring
Examination
- Type
- session examination
- Mode
- written 100 minutes
- Aids
- Keine
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture with exercise |
Chemical Biology and Synthetic Biochemistry
Lecture 2 hours on Wednesday 10-12
1 hour exercise Wednesday 12-13 or 13-14 from second week on - according to agreement.
|
No time listed | 3 h weekly |
Offered In
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Electives (Students are free to choose from a range of D-CHAB chemistry courses appropriate to their level of study (please note admission requirements). In case of doubt, contact the student administration.)
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Computational Biology and Bioinformatics Master (More information at: )
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Advanced Courses (A total of 30 ECTS must be acquired in the advanced course category. Thereof, at least 16 ECTS in the theory and at least 10 ECTS in the biology subcategory.)
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Biology (At least 10 ECTS need to be acquired in this subcategory.)
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