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551-0337-00L 6 Credits BSC D-BIOL

Cell Biology of the Nucleus

Lecturers: Prof. Dr. Yves Barral, Dr. Ruth Kroschewski, Prof. Dr. Karsten Weis, Prof. Dr. Madhav Jagannathan
Examiners: Dr. Ruth Kroschewski
Number of participants limited to 14.. The enrolment is done by the D-BIOL study administration.
VVZ CR n/a

Last Updated: 2026-06-03 00:07:30

Abstract

Introduction to the organizational principles of the nucleus using budding yeast, drosophila and vertebrate cells as model systems.

Objective

The aim of our course is to introduce the students to the organizational principles of the nucleus especially in the three model systems budding yeast, drosophila and vertebrate cells: • Animal cells during the generation of cell diversity • Establishment of nuclear identity and nuclear-cytoplasmic communication • Reorganization of the nucleus in aging By the end of the course, based on lectures, literature reading and practical lab work, the students will be able to formulate open questions concerning the function of the nucleus. Thus, the students will know about the mechanisms and consequences of nuclear-cytoplasmic compartmentalization, nuclear positioning, DNA clustering in the nucleus and cytoplasm e.g. during aging.

Content

During this block-course, the students will - learn how organelles establish and maintain identity with a focus on the nucleus - discover the evolutionary and functional plasticity of the nucleus - design, apply, evaluate and compare experimental strategies Students - in groups of 2 or max. 3 - will be integrated into a research project connected to the subject of the course, within one of the participating research groups. Lectures and technical notes will be given and informal discussions held to provide you with the theoretical background.

Resources

Lecture Notes

About 1 week before course start you will be invited to express your preference for a practical lab project on the course moodle site.Optional papers linked to the projects shall support you in that choice. They can also serve as framework orientation for the practical parts of this block course.

Literature

Documentation and recommended literature (review articles) will be provided during the course.

General Information

Language
English
Levels
BSC
Frequency
Yearly recurring

Examination

Type
graded semester performance
Only the main examiner is listed above, the additional examiners are the other lecturers of the course.Students are obliged to be present throughout the block course.Cancellation: If you have to deregister from a course that has been assigned to you (just emergency reasons), please notify in written the course coordinator at least four weeks before the course starts, for courses in the 1st quarter, a cancellation period of one week applies. The study secretariat D-BIOL must also be informed (email CC [email protected]) so that the enrollment is deleted. Otherwise the course is considered as "failed".

Course Components

Type Title Time & Place Hours
practical/laboratory course Cell Biology of the Nucleus
Permission from lecturers required for all students. Block course in the 1st semester quarter.
No time listed 100 h semesterly

Offered In