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529-0042-00L 4 Credits BSC , DR , MSC D-CHAB

Structure Elucidation by NMR

Lecturers & Examiners: Dr. Marc-Olivier Ebert
VVZ CR n/a

Last Updated: 2026-06-03 00:14:04

Abstract

Structure Elucidation of Complex Organic Molecules by NMR

Objective

Structure elucidation of complex organic molecules (including peptides, oligosaccharides and oligonucleotides) by advanced 1D and 2D NMR spectroscopy: Finding the constitution, rel. configuration and the conformation of an unkown molecule. The emphasis of the course is on the selection of optimal strategies for the solution of a given problem. Discussing and solving these problems by the combined application of various 2D methods form an important part of the course. This also includes the use of state-of-the-art methods for computer assisted structure elucdation (CASE) and chemical shift prediction.

Content

Important experiments for structure elucidation. Finding the optimal strategy for a given problem. Spectral processing for optimal results. Spectral interpretation. Assignment strategies for complex molecules. Common Artefacts. Computer assisted structure elucidation incl. introduction to relevant software and hands-on application. Chemical shift prediction. Discussion of challenging problem sets during class.

Resources

Lecture Notes

Handouts (in English) are distributed in the course

Literature

Claridge, T. D. W. High-Resolution NMR Techniques in Organic Chemistry; Elsevier, 2016. Further reading and references in the handouts.

General Information

Language
English
Levels
BSC , DR , MSC
Frequency
Yearly recurring

Examination

Type
session examination
Mode
written 60 minutes
Aids
Keine. Die Verteilung von Hilfsmitteln, wie zum Beispiel Tabellen, erfolgt gegebenenfalls zusammen mit der Prüfung.
Schriftliche Prüfung auf Englisch, Antwort auf Deutsch möglich.

Course Components

Type Title Time & Place Hours
lecture with exercise Structure Elucidation by NMR
  • Tue 09:45-11:30 (HIL C 10.2)
2 h weekly

Offered In