Galenical Pharmacy I+II

Abstract

Principles and technologies for the manufacturing of dosage forms and drug delivery systems. Knowledge of pharmaceutical excipients, materials, containers, liquid, solid and semi-solid dosage forms, their production, function, quality and application.

Objective

After completing the course, students will be able to: 1. Describe key concepts, materials, and excipients relevant to pharmaceutical formulations and dosage forms. 2. Explain the physicochemical principles and molecular interactions underlying formulation and drug delivery. 3. Apply formulation and manufacturing principles to the design and production of solid, liquid, and semi-solid dosage forms. 4. Analyze how formulation components, processing parameters, and material properties influence product quality, stability, and performance. 5. Evaluate formulation strategies and drug delivery systems with respect to efficacy, safety, and manufacturability. 6. Create formulation concepts or optimization approaches.

Content

Introduction and overview of important fundamentals, principles and technologies for the development and manufacturing of dosage forms and drug delivery systems. Overview of the most important pharmaceutical excipients and polymers, their structure, properties and processing; importance of materials properties for containers. Pharmaceutical solvents, fundamentals of solubility and solubilization of drugs. Water treatment processes, sterilization techniques and quality requirements of pharmaceutical water. Parenteral dosage forms and liquid ophthalmics. Surfactants, micelle formation and colloidal systems. Liquid suspensions and emulsions. Stabilization measures in dosage forms. Important fundamentals, principles and technologies for the development and manufacturing of solid dosage forms and drug delivery systems. Powder technology. Tablets and tabletting. Coating technologies. Drug dissolution and release. Hard and soft gelatin capsules. Introduction to drug delivery and targeting. Drug delivery systems for peroral, transdermal, parenteral and mucosal administration.

Resources