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Pharmaceutical Immunology II & Therapeutic Proteins
Last Updated: 2026-06-01 11:30:39
Abstract
In this course, various topics related to the development, GMP production and application of therapeutic proteins will be discussed. Furthermore, students will expand their training in pharmaceutical immunology and will be introduced to the basic concepts of pharmaceutical product quality management.
Objective
Students know and understand: - basic mechanisms and regulation of the immune response - the pathogenic mechanisms of the most important immune-mediated disorders - the concepts of vaccination and cancer immunotherapy - the most frequently used expression systems for the production of therapeutic proteins - the use of protein engineering tools for modifying different features of therapeutic proteins - the mechanism of action of selected therapeutic proteins and their application - basic concepts in the GMP production of therapeutic proteins
Content
The course consists of two parts: In the first part, students will complete their training in Pharmaceutical Immunology. This part particularly focuses on the pathogenic mechanisms of immune-mediated diseases, vaccination and cancer immunotherapy. Deepened knowledge of immunology will be relevant for understanding the mechanism of action of many therapeutic proteins, as well as for understanding one major concern related to the use of protein-based drugs, namely, immunogenicity. The second part focuses on topics related to the development and application of therapeutic proteins, such as protein expression, protein engineering, reducing immunogenicity, and GMP production of therapeutic proteins. Furthermore, selected examples of approved therapeutic proteins will be discussed.
Resources
Lecture Notes
Handouts to the lectures will be available for downloading underhttp://www.pharma.ethz.ch/scripts/index
Literature
- Janeway's ImmunoBiology, by Kenneth Murphy (9th or 10th Edition) - Lecture Handouts - Paper References provided in the Scripts - EMEA Dossier for Humira
General Information
- Language
- English
- Levels
- MSC , WBZ
- Frequency
- Yearly recurring
Examination
- Type
- session examination
- Mode
- oral 15 minutes
Registration & Places
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture with exercise | Pharmaceutical Immunology II & Therapeutic Proteins |
|
3 h weekly |