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376-1348-00L 3 Credits BSC D-HEST , D-BIOL
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Cellular Ageing

Lecturers & Examiners: Prof. Dr. G.V. Shivashankar
VVZ CR n/a

Last Updated: 2026-06-01 11:31:12

Abstract

Cells undergo major functional alterations as we age. In this course, we will discuss the basic molecular and cell biological mechanisms of cellular ageing. We will also discuss diseases related to cellular ageing and current rejuvenation and therapeutic strategies for cellular ageing in health and disease.

Objective

- Basic molecular and cell biological mechanisms of cellular ageing; - Diseases related to cellular ageing; - current rejuvenation and therapeutic strategies for cellular ageing in health and disease.

Content

Lecture-1: Hallmarks of cellular ageing Lecture-2: Cellular microenvironment & extra-cellular matrix Lecture-3: Cell morphometric changes & cytoskeletal remodeling Lecture-4: Proteostasis Lecture-5: Mitochondrial dysfunction Lecture-6: Endo-membrane signaling Lecture-7: Nuclear signaling & epigenetic alternations Lecture-8: Chromatin remodeling & gene expression Lecture-9: Genomic integrity Lecture-10: Ageing cell secretome and cellular homeostasis Lecture-11: Diseases associated with cellular ageing Lecture-12: Cellular rejuvenation strategies Lecture-13: Therapeutic interventions to cellular ageing Lecture-14: Concluding lecture

General Information

Language
English
Levels
BSC
Frequency
Yearly recurring

Examination

Type
end-of-semester examination
Mode
written 60 minutes
Aids
no written aids allowed
Grading consists of- compulsory class presentations graded 1-6 and counting 25% towards the final grade.- compulsory project report graded 1-6 and counting 25% towards the final grade.- final exam counting 50% towards the final grade.The examination may be conducted as a computer examination.

Course Components

Type Title Time & Place Hours
lecture Cellular Ageing
  • Wed 15:45-17:30 (HIL E 1)
2 h weekly

Offered In