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227-0085-67L 4 Credits BSC D-ITET
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P&S: Clinical Genomics

Lecturers & Examiners: Prof. Dr. Onur Mutlu
The course unit can only be taken once. Repeated enrollment in a later semester is not creditable.
VVZ CR n/a

Last Updated: 2026-06-01 11:33:22

Abstract

The category of "Laboratory Courses, Projects, Seminars" includes courses and laboratories in various formats designed to impart practical knowledge and skills. Moreover, these classes encourage independent experimentation and design, allow for explorative learning and teach the methodology of project work.

Objective

Bioinformatics and the computational analysis of next-generation sequencing data are the foundation of many medical discoveries, personalized medicine, high throughput diagnostic techniques, and the early detection of cancer and autoimmune diseases. A dedicated machine (called a sequencer) extracts lots of random fragments of a DNA sequence, known as reads. Small, handheld sequencers such as ONT MinION and Flongle make it possible to sequence bacterial and viral genomes on-site. This enables disease outbreak analyses (i.e., for COVID-19 or Ebola) and the on-site analysis of patient samples. A prominent example is the study of the human microbiome in liquid biopsy samples (i.e., blood samples). The microbiome is strongly related to human health and allows for the early diagnosis of diseases like Parkinson's, Alzheimer's, and cancer. In this course, we will cover the basics of genome analysis for medical applications, high-throughput diagnostics, and the early detection and prevention of diseases. Students will experimentally evaluate different algorithms and machine-learning techniques to uncover somatic mutations in cancer and develop tools dedicated to microbiome discovery and high-throughput disease diagnostics. The course is conducted in English. Arvid Gollwitzer is the main supervisor for this course. Please contact him if you are interested in taking this course: [email protected]

Content

Course website: Link

General Information

Language
English
Levels
BSC
Frequency
Semesterly recurring

Examination

Type
ungraded semester performance

Registration & Places

Limited places (Special selection)
Signup Start
14.02.2025
Signup End
28.02.2025

Course Components

Type Title Time & Place Hours
practical/laboratory course P&S: Clinical Genomics
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No time listed 4 h weekly

Offered In