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529-0222-00L 3 Credits BSC D-CHAB
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Organic Chemistry II

Lecturers: Prof. Dr. Jeffrey W. Bode, Prof. Dr. Bill Morandi
Examiners: Prof. Dr. Jeffrey W. Bode, Prof. Dr. Helma Wennemers, Prof. Dr. Bill Morandi
VVZ CR n/a

Last Updated: 2026-06-01 11:33:00

Abstract

This course builds on the material learned in Organic Chemistry I or Organic Chemistry II for Biology/Pharmacy Students. Topics include advanced concepts and mechanisms of organic reactions and introductions to pericyclic and organometallic reactions. The basics or retro- and forward synthesis are also introduced.

Objective

Goals of this course include a deeper understanding of basic organic reactions and mechanisms as well as advanced transformations. Reactive intermediates including carbenes and nitrenes are covered, along with methods for their generation and use in complex molecule synthesis. Frontier molecular orbital theory (FMO) is introduced and used to rationalize pericyclic reactions including Diels Alder reactions, cycloadditions, and rearrangements (Cope, Claisen). The basic concepts and key reactions of catalytic organometallic chemistry, which are key methods in modern organic synthesis, are introduced, with an emphasis on their catalytic cycles and elementary steps. All of these topics are combined in an overview of strategies for complex molecule synthesis, with specific examples from natural product derived molecules used as medicines.

Content

Redox neutral reactions and rearrangements, advanced transformations of functional groups and reaction mechanisms, carbenes and nitrenes, frontier molecular orbital theory (FMO), cycloadditions and pericyclic reactions, introduction to organometallic chemistry and catalytic cross couplings, protecting groups, retrosynthetic analysis of complex organic molecules, planning and execution of multi-step reactions.

Resources

Lecture Notes

The lecture notes and additional documents including problem sets are available as PDF files online, without charge. Link:https://morandi.ethz.ch/education.html

Literature

Clayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012.

General Information

Language
English
Levels
BSC
Frequency
Yearly recurring

Examination

Type
session examination
Mode
written 120 minutes
Aids
Keine.

Course Components

Type Title Time & Place Hours
lecture Organic Chemistry II
  • Wed 07:45-09:30 (HCI J 7)
2 h weekly
exercise Organic Chemistry II
Groups are selected in myStudies. Die Übungsgruppen können nach der ersten Vorlesung belegt werden
  • Wed 12:45-13:30 (HCI E 8)
  • Wed 12:45-13:30 (HCI F 2)
  • Wed 12:45-13:30 (HCI H 8.1)
  • Wed 12:45-13:30 (HPK D 24.2)
  • Thu 11:45-12:30 (HCI D 2)
  • Thu 11:45-12:30 (HCI D 8)
  • Thu 11:45-12:30 (HCI F 8)
  • Thu 11:45-12:30 (HIL D 60.1)
  • Thu 11:45-12:30 (HIT J 51)
1 h weekly

Offered In