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551-0223-00L 4 Credits MSC D-USYS , D-MAVT , D-PHYS , D-BIOL , D-ITET , D-HEST
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Immunology III

Lecturers & Examiners: Prof. em. Dr. Manfred Kopf, Prof. Dr. Annette Oxenius, PD Dr. Stefan Bernd Freigang, Prof. Dr. Salomé Régine Leibundgut, Dr. Roman Spörri, Prof. Dr. Emma Slack, Prof. Dr. Christoph Schneider, Dr. Florian Mair
VVZ CR n/a

Last Updated: 2026-02-05 16:30:50

Abstract

This course provides a detailed understanding of- development of T and B cells- the dynamics of a immune response during acute and chronic infection- mechanisms of immunopathology- modern vaccination strategiesKey experimental results will be shown to help understanding how immunological text book knowledge has evolved.

Objective

Obtain a detailed understanding of - the development, activation, and differentiation of different types of T cells and their effectormechanisms during immune responses, - Recognition of pathogenic microorganisms by the host cells and molecular events thereafter, - events and signals for maturation of naive B cells to antibody producing plasma cells and memory B cells. - Optimization of B cell responses by intelligent design of new vaccines

Content

o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg) o NK T cells and responses to lipid antigens o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17 o Overview of cytokines and their effector function o Co-stimulation (signals 1-3) o Dendritic cells o Evolution of the "Danger" concept o Cells expressing Pattern Recognition Receptors and their downstream signals o T cell function and dysfunction in acute and chronic viral infections

Resources

Literature

Documents of the lectures are available for download at: https://moodle-app2.let.ethz.ch/course/view.php?id=2581¬ifyeditingon=1

Learning Materials (Links)

General Information

Language
English
Levels
MSC
Frequency
Yearly recurring

Examination

Type
session examination
Mode
written 120 minutes
Aids
Keine Hilfsmittel erlaubt.No aids allowed.

Course Components

Type Title Time & Place Hours
lecture Immunology III
  • Mon 09:45-11:30 (HIL E 6)
2 h weekly

Offered In