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551-1318-00L 6 Credits BSC D-BIOL
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CRISPR-Cas Genome Engineering in Human Cells

Lecturers & Examiners: Prof. Dr. Jacob Corn
Number of participants limited to 10 (6 in the 1st and 4 in the 3rd quarter of the spring semester). The enrolment is done by the D-BIOL study administration.
VVZ CR n/a

Last Updated: 2026-02-05 16:08:10

Abstract

This laboratory course focuses on research topics in the Corn lab related to CRISPR-Cas genome engineering, the role of DNA repair in metazoan genome editing, the development of preclinical proof-of-concept for genome editing therapies, and the use of genome editing to investigate fundamental questions in blood cells. Projects will be conducted in small groups.

Objective

This course will introduce technologies and approaches in modern genome engineering. The main focus is on practical work to familiarize participants with techniques such as functional genomics, biochemistry, human cell biology, and next generation sequencing. Results will be presented by students in several scientific presentations.

Content

The course will include topics related to ongoing research projects in the lab. Experimental work will include methods such as CRISPR-Cas genome engineering, CRISPR-Cas screening, cloning, mammalian transformation, human cell biology, flow cytometry, and biochemistry.

Resources

Lecture Notes

None

Literature

Will be provided at the beginning of the course.

General Information

Language
English
Levels
BSC
Frequency
Yearly recurring

Examination

Type
graded semester performance
Student evaluations will be based on multiple project presentations, a written report, and an oral examination. Details will be communicated at the beginning of the course.Students are obliged to be present throughout the block course.Cancellation: If you have to deregister from a course that has been assigned to you (just emergency reasons), please notify in written the course coordinator at least four weeks before the course starts, for courses in the 1st quarter, a cancellation period of one week applies. The study secretariat D-BIOL must also be informed (email CC [email protected]) so that the enrollment is deleted. Otherwise the course is considered as "failed".

Course Components

Type Title Time & Place Hours
practical/laboratory course CRISPR-Cas Genome Engineering in Human Cells
Permission from lecturers required for all students. Block course in the 1st and 3rd quarter of the spring semester. Place: HPL J27.1, HPL J31.2 and HPL J33.2
No time listed 100 h semesterly

Offered In