Problem-Based Approach to Spatial Biology

Abstract

This course entails lectures in tissue physiology, spatial methodologies and grantsmanship. In the project part, small working groups will perform the entire scientific process around formulating a research proposal with the aid of tutors.

Objective

The students will understand the current state of research and novel methodologies in spatial biology and tissue physiology. They will obtain the necessary toolkits to independently identify open research problems in various areas of spatial biology, to address these problems with suitable experimental strategies, and to formulate their approach in a research proposal.

Content

We will use a problem-based approach to explore the way in which single cells collaborate within tissues to achieve their common functions. A thorough comprehension of these tissue components is crucial for advancing our knowledge of normal homeostasis and pathophysiology; disrupted cellular interactions can lead to decreased tissue function or even carcinogenesis. The project work will be conducted in small groups in guidance of tutors. Each group will focus on a different topic in spatial biology and will review the corresponding literature. They will identify open problems of interest in this area and will summarize their findings in a short, written review. The students will then develop an appropriate experimental strategy to address a question of interest and write a research proposal that features their approach. The final stage of the project work enable the students to practice the presentation of their research proposals and critical evaluation.

Resources