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Immunology III
Last Updated: 2026-02-05 15:48:50
Abstract
This course provides a detailed understanding of- development of T and B cells- the dynamics of a immune response during acute and chronic infection- mechanisms of immunopathology- modern vaccination strategiesKey experimental results will be shown to help understanding how immunological text book knowledge has evolved.
Objective
Obtain a detailed understanding of - the development, activation, and differentiation of different types of T cells and their effectormechanisms during immune responses, - Recognition of pathogenic microorganisms by the host cells and molecular events thereafter, - events and signals for maturation of naive B cells to antibody producing plasma cells and memory B cells. - Optimization of B cell responses by intelligent design of new vaccines
Content
o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg) o NK T cells and responses to lipid antigens o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17 o Overview of cytokines and their effector function o Co-stimulation (signals 1-3) o Dendritic cells o Evolution of the "Danger" concept o Cells expressing Pattern Recognition Receptors and their downstream signals o T cell function and dysfunction in acute and chronic viral infections
Resources
Literature
Documents of the lectures are available for download at: https://moodle-app2.let.ethz.ch/course/view.php?id=2581¬ifyeditingon=1
General Information
- Language
- English
- Levels
- MSC
- Frequency
- Yearly recurring
Examination
- Type
- session examination
- Mode
- written 120 minutes
- Aids
- Keine Hilfsmittel erlaubt.No aids allowed.
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture | Immunology III |
|
2 h weekly |