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551-1403-00L 6 Credits BSC D-BIOL

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Imaging Bacterial Cells in a Native State by Electron Cryotomography

Lecturers & Examiners: Prof. Dr. Martin Pilhofer

Number of participants limited to 5. The enrolment is done by the D-BIOL study administration. General safety regulations for all block courses: -Whenever possible the distance rules have to be respected -All students have to wear masks throughout the course (keep reserve masks ready) -The installation and activation of the Swiss Covid-App is highly encouraged -Any additional rules for individual courses have to be respected -Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible

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Last Updated: 2026-02-05 15:36:22

Abstract

The goal is to acquire the techniques to image bacteria by electron cryotomography, resolving their structure in a native state, in 3D, and to macromolecular resolution. In a small group, students will perform wet lab experiments, data collection with stat-of-the-art equipment, data processing and analyses. The key method and its application in bacterial cell biology will be introduced by lectures

Objective

Students will acquire the skills to cultivate bacteria, plunge-freeze samples for cryotomography, collect data using an electron cryomicroscope, process raw data, analyze tomograms, perform subtomogram averaging, model structures of interest, and generate movies for visualization. https://www.mol.biol.ethz.ch/groups/pilhofer_group/

General Information

Language: English
Levels: BSC
Frequency: Yearly recurring

Examination

Type: graded semester performance

Course Components

Type	Title	Time & Place	Hours
practical/laboratory course	Imaging Bacterial Cells in a Native State by Electron Cryotomography Permission from lecturers required for all students. Block course in the 4th quarter of the autumn semester	Tue 12:45-16:30 (HPK D 6.1) Wed 07:45-16:30 (HPK D 6.1) Thu 07:45-16:30 (HPK D 6.1) Fri 07:45-16:30 (HPK D 6.1)	100 h semesterly

Offered In

Biology Bachelor
- Bachelor Studies (Programme Regulations 2013)
  - 3. Year, 5. Semester
    - Block Courses (Registration for Block courses is mandatory. Please register under . Registration period: from 20.7.2020 - 9.8.2020. Please note the ETH admission criteria for the admission of ETH students to ETH block courses on the block course registration website under "allocation".)
      - Block Courses in 4th Quarter of the Semester (From 26.11.2020 - 18.12.2020)