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262-5110-00L 3 Credits MSC D-BSSE , D-INFK
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Protein Crystallography and Electron Microscopy (University of Zurich)

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Last Updated: 2026-02-05 15:41:57

Abstract

The lecture introduces two methods for the structure determination ofbiological macromolecules and cellular components: X-ray crystallography and electron microscopy (EM).

Objective

To understand the basic concepts of protein crystallography and electron microscopy in theory and practice.

Content

The lecture introduces two methods for the structure determination of biological macromolecules and cellular components: X-ray crystallography and electron microscopy (EM). The lecture provides students with the main concepts of protein structure determination by X-ray crystallography (protein crystallization, crystal symmetry and diffraction, data collection, phasing methods, refinement). The second part of the lecture will deal with electron microscopy. The topics include Transmission EM, Scanning EM, sample preparation, data acquisition, 3D reconstruction, aberration, detectors.

General Information

Language
English
Levels
MSC
Frequency
Yearly recurring

Examination

Type
graded semester performance
Registration modalities, date and venue of this performance assessment are specified solely by UZH.

Course Components

Type Title Time & Place Hours
lecture with exercise Protein Crystallography and Electron Microscopy (University of Zurich)
**Course at University of Zurich**
No time listed 3 h weekly

Offered In