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Mathematics of (Super-Resolution) Biomedical Imaging
Last Updated: 2026-02-05 15:41:22
Abstract
The aim of this course is to review different methods used to address challenging problems in biomedical imaging. The emphasis will be on scale separation techniques, hybrid imaging, spectroscopic techniques, and nanoparticle imaging. These approaches allow one to overcome the ill-posedness character of imaging reconstruction in biomedical applications and to achieve super-resolution imaging.
Objective
Super-resolution imaging is a collective name for a number of emerging techniques that achieve resolution below the conventional resolution limit, defined as the minimum distance that two point-source objects have to be in order to distinguish the two sources from each other. In this course we describe recent advances in scale separation techniques, spectroscopic approaches, multi-wave imaging, and nanoparticle imaging. The objective is fivefold: (i) To provide asymptotic expansions for both internal and boundary perturbations that are due to the presence of small anomalies; (ii) To apply those asymptotic formulas for the purpose of identifying the material parameters and certain geometric features of the anomalies; (iii) To design efficient inversion algorithms in multi-wave modalities; (iv) to develop inversion techniques using multi-frequency measurements; (v) to develop a mathematical and numerical framework for nanoparticle imaging. In this course we shall consider both analytical and computational matters in biomedical imaging. The issues we consider lead to the investigation of fundamental problems in various branches of mathematics. These include asymptotic analysis, inverse problems, mathematical imaging, optimal control, stochastic modelling, and analysis of physical phenomena. On the other hand, deriving mathematical foundations, and new and efficient computational frameworks and tools in biomedical imaging, requires a deep understanding of the different scales in the physical models, an accurate mathematical modelling of the imaging techniques, and fine analysis of complex physical phenomena. An emphasis is put on mathematically analyzing acoustic-electric imaging, thermo-elastic imaging, Lorentz force based imaging, elastography, multifrequency electrical impedance tomography, and plasmonic resonant nanoparticles.
Resources
Learning Materials (Links)
- Recording
- 16 March: Lecture 04, slides 1-12: Scale separation techniques
- 16 March: Lecture 04, slides 13-21: Scale separation techniques
- 23 March: Lecture 04, slides 22-34: Scale separation techniques
- 23 March: Lecture 04, slides 35-42: Scale separation techniques
- 30 March: Lecture 05, slides 1-20: Photo-acoustic imaging
- 30 March: Lecture 05, slides 21-27: Photo-acoustic imaging
- 6 April: Lecture 06, slides 1-19: Quantitative thermo-acoustic imaging
- 20 April: Lecture 07, slides 1-22: Ultrasonically-induced Lorentz force imaging
- 27 April: Lecture 08, slides 1-40: Ultrasound-modulated optical tomography
- 4 May: Lecture 09, slides 1-20: Acousto-electric imaging
- 11 May: Lecture 10, slides 1-27: Viscoelastic modulus reconstruction and full-field OCT elastography
- 18 May: Lecture 11, slides 1-32: Effective electrical tissue properties imaging
- 25 May: Lecture 12, slides 1-21: Plasmonic nanoparticle imaging
- Documents
- Lecture 00 - Introduction
- Lecture 01 - Basic mathematical concepts
- Lecture 02 - Tissues properties
- Lecture 03 - Layer potential techniques
- Lecture 04 - Scale separation techniques
- Lecture 05 - Photo-acoustic imaging
- Lecture 06 - Quantitative thermo - acoustic imaging
- Lecture 07 - Ultrasonically-induced Lorentz force imaging
- Lecture 08 - Ultrasound-modulated optical tomography
- Lecture 09 - Acousto-electric imaging
- Lecture 10 - Viscoelastic modulus reconstruction and full-field OCT elastography
- Lecture 11 - Effective electrical tissue properties imaging
- Lecture 12 - Plasmonic nanoparticle imaging
- Literature
- Mathematics of Super-Resolution Biomedical Imaging - Lecture Notes
- Mathematics of Super-Resolution Biomedical Imaging - Tutorial Notes
- Additional links
- Tutorial 01 Codes - SVD Regularizarion
- Tutorial 02 Codes - Random Medium Generation
- Tutorial 03 Codes - Spherical Means Radon Transform Inversion
- Tutorial 04 Codes - Neumann Poincare Operator
- Tutorial 05 Codes - Electrical Impedance Tomography
- Tutorial 06 Codes - Anomaly Detection Algorithms (MUSIC, Kirchhoff Migration)
- Tutorial 07 Codes - Inversion Spherical Radon Transform with Total Variation Regularization
- Tutorial 08 Codes - Gradient Descent Magneto Acoustic Tomography
- Tutorial 09 Codes - OCT Elastography
General Information
- Language
- English
- Levels
- DR , MSC
- Frequency
- Yearly recurring
Examination
- Type
- session examination
- Mode
- oral 20 minutes
Course Components
| Type | Title | Time & Place | Hours |
|---|---|---|---|
| lecture with exercise |
Mathematics of (Super-Resolution) Biomedical Imaging
no class on 5 March 2020
|
|
4 h weekly |
Offered In
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Electives (For the Master's degree in Applied Mathematics the following additional condition (not manifest in myStudies) must be obeyed: At least 15 of the required 28 credits from core courses and electives must be acquired in areas of applied mathematics and further application-oriented fields.)
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Doctoral Department of Mathematics (More Information at: The list of courses (together with the allocated credit points) eligible for doctoral students is published each semester in the newsletter of the ZGSM. WARNING: Do not mistake ECTS credits for credit points for doctoral studies!)
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Graduate School (Official website of the Zurich Graduate School in Mathematics:)
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